- Description
CSB VLPs: Our virus-like particles display FULL-LENGTH membrane proteins in a NATIVE mammalian lipid bilayer, preserving the conformational structure. Each preparation is SPECIFIC to your target, providing a stable antigen for immunization, display selection, screening, and SPR/BLI characterization.
| Target | TIGIT |
| Target Aliases | VSIG9, VSTM3, WUCAM |
Stable for 12 months from date of receipt at -80°C or lower. Avoid repeated freeze-thaw cycles.
T-cell immunoreceptor with Ig and ITIM domains is an immunoglobulin superfamily receptor encoded by the TIGIT gene. It is a type I single-pass transmembrane glycoprotein with an extracellular immunoglobulin variable-like domain and a cytoplasmic tail containing immunoreceptor tyrosine-based inhibitory motifs. TIGIT is expressed mainly on activated T cells, regulatory T cells, natural killer cells, and subsets of memory lymphocytes, where binding to ligands such as PVR (CD155) and NECTIN2 (CD112) modulates immune cell activation and effector responses. Its intracellular signaling is associated with inhibitory regulation of cytokine production and cytotoxic activity.
