- Description
CSB VLPs: Our virus-like particles display FULL-LENGTH membrane proteins in a NATIVE mammalian lipid bilayer, preserving the conformational structure. Each preparation is SPECIFIC to your target, providing a stable antigen for immunization, display selection, screening, and SPR/BLI characterization.
| Target | CXCR2 |
| Target Aliases | CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, SCN13, WHIMS2 |
Stable for 12 months from date of receipt at -80°C or lower. Avoid repeated freeze-thaw cycles.
C-X-C motif chemokine receptor 2 is a member of the class A rhodopsin-like G protein-coupled receptor family encoded by the CXCR2 gene. It is a seven-transmembrane cell surface receptor that binds ELR-positive CXC chemokines including CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, and CXCL8, primarily signaling through Gi proteins to regulate calcium mobilization, integrin activation, and chemotactic migration. CXCR2 is highly expressed on neutrophils and is also detected on monocytes, endothelial cells, and other cell types, where it mediates leukocyte recruitment and inflammatory responses. Receptor activation is controlled through phosphorylation-dependent desensitization and internalization.
