- Description
CSB VLPs: Our virus-like particles display FULL-LENGTH membrane proteins in a NATIVE mammalian lipid bilayer, preserving the conformational structure. Each preparation is SPECIFIC to your target, providing a stable antigen for immunization, display selection, screening, and SPR/BLI characterization.
| Target | CD62L |
| Target Aliases | CD62L, LAM-1, LECAM1, LNHR, selectin L |
Stable for 12 months from date of receipt at -80°C or lower. Avoid repeated freeze-thaw cycles.
L-selectin (SELL) is a type I transmembrane glycoprotein and a member of the selectin family of cell adhesion molecules. It is expressed on most leukocytes, including naïve T cells, B cells, neutrophils, and monocytes, where it mediates leukocyte rolling and homing to secondary lymphoid tissues through binding to carbohydrate ligands on endothelial cells. CD62L is a marker for T cell activation/differentiation state. The extracellular region contains a C-type lectin domain, an epidermal growth factor-like domain, and a series of short consensus repeat units, while the cytoplasmic tail contributes to intracellular signaling and shedding regulation. Proteolytic cleavage of the extracellular domain regulates its surface expression and leukocyte trafficking.
