- Description
CSB VeRSaMAbs:
We produce and validate all our monoclonal antibodies in-house so that you can confidently choose the right antibody for your assay. All antibodies are VALIDATED for common applications, RECOMBINANT for batch-to-batch consistency, and SPECIFIC in binding to only your target.
| Target | HER3 |
| Target Aliases | ERBB3, LCCS2, P180-ErbB3, P45-SErbB3, P85-SErbB3, MDA-BF-1, C-ErbB-3, C-ErbB3, ErbB3-S, ErbB-3, FERLK, VSCN1. |
| Isotype | IgG2a |
| Species Reactivity | Human (Others untested) |
| Concentration | 1 mg/ml |
Stable for 12 months from date of receipt when stored at 4°C. Avoid repeated freeze-thaw cycles.
HER3 is a single-pass transmembrane protein and part of the epidermal growth factor receptor family of receptor tyrosine kinases. HER3 has a neuregulin binding domain but does not have a kinase domain and instead forms heterodimers with other EGFR family members, activating signaling pathways that cause cell proliferation or differentiation. HER3 is involved in myeloid cell differentiation. Amplification or overexpression of HER3 occurs in prostate, bladder, and breast tumors.
