- Description
| Specificity Profile | More Information |
 | The specificity of GCGR Monoclonal Antibody (CSB0137) was tested on the Membrane Proteome Array™ and shown to be specific for human GCGR. The Membrane Proteome Array™ contains 6,000 different human membrane proteins, each expressed in unfixed human cells to ensure native conformation and post-translational modifications. The Membrane Proteome Array™ represents the industry standard for determining the binding specificity of antibodies and other protein ligands. |
| Application | Conditions | Recommended Concentration |
| Flow Cytometry, Extracellular | Live, Unpermeabilized | 1 µg/ml |
 | HEK-293F cells transiently transfected with human GCGR were stained with GCGR Monoclonal Antibody (CSB0137) (green) or isotype control antibody (gray), followed by AlexaFluor 647-conjugated anti-Mouse IgG secondary antibody. HEK-293F cells transiently transfected with an empty control vector were also stained with GCGR Monoclonal Antibody (CSB0137) (blue). | |
CSB VeRSaMAbs:
We produce and validate all our monoclonal antibodies in-house so that you can confidently choose the right antibody for your assay. All antibodies are VALIDATED for common applications, RECOMBINANT for batch-to-batch consistency, and SPECIFIC in binding to only your target.
| Target | GCGR |
| Target Aliases | GGR, GL-R, MVAH |
| Isotype | Mouse IgG2a |
| Membrane Proteome Specificity | Monospecific for 6,000 membrane proteins tested |
| Species Reactivity | Human (others untested) |
| Fc Modifications | C-terminal Avitag, disabled Fc-gamma receptor binding |
| Source | Recombinant CHO expression; purified by Protein A chromatography |
| Formulation | Endotoxin Free PBS pH 7.4, sterile-filtered |
| Concentration | 1 mg/ml |
Stable for 12 months from date of receipt when stored at 4°C. Avoid repeated freeze-thaw cycles.
GCGR is a multi-pass membrane protein and G-protein coupled glucagon receptor. GCGR promotes glycogen hydrolysis and gluconeogenesis in order to control blood glucose levels. Variants of GCGR are associated with type 2 diabetes and Mahvash disease. (NCBI Gene: 2642, UniProtKB/Swiss-Prot: P47871). Other names: GGR, GL-R, MVAH
