- Description
| Specificity Profile | More Information |
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The specificity of CDH17 Monoclonal Antibody (CSB0181) was tested on the Membrane Proteome Array® and shown to be specific for human CDH17. The Membrane Proteome Array® contains 6,000 different human membrane proteins, each expressed in unfixed human cells to ensure native conformation and post-translational modifications. The Membrane Proteome Array® represents the industry standard for determining the binding specificity of antibodies and other protein ligands. |
| Application | Conditions | Recommended Concentration |
| Flow Cytometry, Extracellular | Live, Unpermeabilized | 1 µg/ml |
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HEK-293F cells transiently transfected with human CDH17 were stained with CDH17 Monoclonal Antibody (CSB0181) (green) or isotype control antibody (gray), followed by AlexaFluor 647- conjugated anti-Mouse IgG secondary antibody. HEK-293F cells transiently transfected with an empty control vector were also stained with CDH17 Monoclonal Antibody (CSB0181) (blue). | |
| Application | Conditions | Recommended Concentration |
| Immunofluorescence, Extracellular | Fixed 4% paraformaldehyde | 1 µg/ml |
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(Left) JS-1 cells transiently transfected human CDH17 were stained with CDH17 Monoclonal Antibody (CSB0181) followed by AlexaFluor 647 anti-Mouse IgG secondary antibody (red) and DAPI (blue). (Top right) JS-1 cells transiently transfected with an empty control vector stained with CDH17 Monoclonal Antibody. (Bottom right) Isotype control: JS-1 cells transfected with human CDH17 and stained with control MAb. | |
| Application | Conditions | Recommended Concentration |
| Immunofluorescence, Intracellular | Fixed 4% paraformaldehyde, Permeabilized 0.1% Triton X-100 | 1 µg/ml |
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(Left) JS-1 cells transiently transfected human CDH17 were permeabilized and stained with CDH17 Monoclonal Antibody (CSB0181) followed by AlexaFluor 647 anti-Mouse IgG secondary antibody (red) and DAPI (blue). (Top right) JS-1 cells transiently transfected with an empty control vector stained with CDH17 Monoclonal Antibody. (Bottom right) Isotype control: JS-1 cells transfected with human CDH17 and stained with control MAb. | |
CSB VeRSaMAbs:
We produce and validate all our monoclonal antibodies
in-house so that you can confidently choose the right antibody for your assay. All antibodies are
VALIDATED for common applications, RECOMBINANT for batch-to-batch consistency, and
SPECIFIC in binding to only your target.
| Target | CDH17 |
| Target Aliases | Cadherin 17, HPT-1, Intestinal Peptide-Associated Transporter HPT-1 |
| Isotype | Mouse IgG2a |
| Membrane Proteome Specificity | Monospecific for 6,000 membrane proteins tested |
| Species Reactivity | Human (Others untested) |
| Fc Modifications | C-terminal Avitag, disabled Fc-gamma receptor binding |
| Source | Recombinant CHO expression; purified by Protein A chromatography |
| Formulation | Endotoxin Free PBS pH 7.4, sterile-filtered |
| Concentration | 1 mg/ml |
Stable for 12 months from date of receipt when stored at 4°C. Avoid repeated freeze-thaw cycles.
Cadherin-17 is a non-classical member of the cadherin superfamily involved in calcium-dependent cell adhesion. It features seven extracellular cadherin domains and a single-pass transmembrane segment but lacks the conserved cytoplasmic domain required for catenin binding, distinguishing it from classical cadherins. CDH17 is mainly expressed in the gastrointestinal tract, where it facilitates homophilic cell-cell adhesion and contributes to epithelial cohesion. It does not have a confirmed role in intracellular signaling pathways. (NCBI Gene: 1015, UniProtKB/Swiss-Prot: Q12864 ) Other names: Cadherin 17, HPT-1, Intestinal Peptide-Associated Transporter HPT-1
