Custom Antibody Reagents

Any Target, Any Species

Access any target with VeRSaMAbs®—high-quality antibody reagents for GPCRs, ion channels, transporters, and more. The only service that delivers reagent antibodies that cross-react with any mammalian species—including humans, mice, NHPs, and more.

The Leading Platform for Accessing Difficult Targets

Cell Surface Bio leverages the 20+ years of antibody discovery and validation expertise of our parent company, Integral Molecular, whose MPS Antibody Discovery Platform is tailored to deliver therapeutic antibodies against even the most challenging protein targets. Our antibody discovery platform uses only high-quality native immunogens (mRNA and Lipoparticle™ immunizations), and evolutionarily divergent chicken host animals to elicit a robust immune response against any mammalian target (Banik et al., 2023). This high-throughput platform has been used to successfully discover thousands of antibodies.

our custom antibody services leverage our proven antibody discovery platform to consistently deliver high-quality antibodies against even the most challenging protein targets to enable target validation. Capable of isolating GPCR antibodies, ion channel antibodies, and other highly conserved and poorly expressed antigens with small extracellular loops. Immunization with mRNA and Lipoparticles produces a robust immune response and high titers for both easy (e.g. SARS-CoV-2 spike protein) and hard targets (GPCRs and ion channels) in chickens, a divergent host species. Produces high-quality monoclonal antibody reagents; flow cytometry antibodies, IHC antibodies, mouse antibodies, NHP antibodies (including rhesus antibodies, marmoset antibodies, and macaque antibodies) all with high titers against native antigens.

 

Every VeRSaMAb® Is Extensively Validated, Recombinant, and Specific to Your Target

Every VeRSaMAb we isolate is validated for performance in your application, is recombinant for consistency across batches, and specific only to your target. Reagent antibodies generated at Cell Surface Bio are selected to recognize native antigens with high affinity. Once isolated, VeRSAMabs are validated for specificity using the Membrane Proteome Array™ (MPA) and for compatibility with flow cytometry, immunofluorescence, IHC/ICC, and western blot.

 

Our mAbs Are Pan-Reactive to Bridge Animal and Human Studies

Designed for cross-species reactivity, VeRSaMAbs enable seamless progression from preclinical models to human systems—supporting targetour custom antibody services leverage our proven antibody discovery platform to generate pan-reactive antibodies that cross-react with numerous mammalian species to enable target validation. Use a single reagent as a human antibody, a mouse antibody (anti-mouse), a rat antibody (anti-rat), a NHP antibody (anti-NHP) (including Rhesus antibodies, marmoset antibodies, and macaque antibodies), a cynomolgus antibody (anti-cyno), a bat antibody (anti-bat), a ferret antibody (anti-ferret), a rabbit antibody (anti-rabbit). validation and translational research across species.

  • Validate Across Species: Assess target relevance in mice, rats, NHPs, and other mammalian models. Isolate mAbs against targets from any mammalian species: mouse, cynomolgus, rhesus, marmoset, rat, rabbit, ferret, pig, bat, guinea pig, and more.
  • One mAb for Preclinical Studies: Confirm safety and efficacy in preclinical models and localization in human tissues with the same mAb.

 

Project Workflow

 

our custom antibody services leverage our proven antibody discovery platform to generate pan-reactive antibodies that cross-react with numerous mammalian species. Our antibody discovery platform utilizes chickens as a divergent host species and immunizes with mRNA and Lipoparticles (virus-like particles, VLPs) that present high-concentration and structurally-intact membrane proteins, to generate antibodies against native antigens. Monoclonal antibody reagents are screened using optimized phage display protocols to isolate rare mAbs even against membrane proteins embedded in a lipid bilayer. Antibodies are validated and characterized to ensure high-quality antibody reagents that are compatible with flow cytometry, IHC, immunofluorescence, western blot, and numerous other assays.

 

Contact Us to Get a Quote and Start a Project

 

Frequently Asked Questions