Custom Antibody Reagents

Any Target, Any Species

Access any target with VeRSa-Select™— for high-quality antibody reagents for GPCRs, ion channels, transporters, and more. The only service that delivers reagent antibodies that cross-react with any mammalian species—including humans, mice, NHPs, and more.

The Leading Platform for Accessing Difficult Targets

Cell Surface Bio leverages the 20+ years of antibody discovery and validation expertise of our parent company, Integral Molecular, whose MPS Antibody Discovery Platform is tailored to deliver therapeutic antibodies against even the most challenging protein targets. Our antibody discovery platform uses only high-quality native immunogens (mRNA and Lipoparticle™ immunizations), and evolutionarily divergent chicken host animals to elicit a robust immune response against any mammalian target (Banik et al., 2023). This high-throughput platform has been used to successfully discover thousands of antibodies.

our custom antibody services leverage our proven antibody discovery platform to consistently deliver high-quality antibodies against even the most challenging protein targets to enable target validation. Capable of isolating GPCR antibodies, ion channel antibodies, and other highly conserved and poorly expressed antigens with small extracellular loops. Immunization with mRNA and Lipoparticles produces a robust immune response and high titers for both easy (e.g. SARS-CoV-2 spike protein) and hard targets (GPCRs and ion channels) in chickens, a divergent host species. Produces high-quality monoclonal antibody reagents; flow cytometry antibodies, IHC antibodies, mouse antibodies, NHP antibodies (including rhesus antibodies, marmoset antibodies, and macaque antibodies) all with high titers against native antigens.

 

CSB’s workflows developed for reliable antibody performance are customizable for VeRSa-Select antibodies, with options including:

  • Validation in flow cytometry, immunofluorescence, immunohistochemistry, and other key applications
  • Rigorous testing for specificity against 6,000+ native proteins using the Membrane Proteome Array™
  • Recombinant cloning for animal-free production, batch-to-batch consistency, enhanced detection, and reproducible results

 

Our mAbs Are Pan-Reactive to Bridge Animal and Human Studies

VeRSa-Select™ delivers mAbs designed for cross-species reactivity, enabling seamless progression from preclinical models to human systems—supporting targetour custom antibody services leverage our proven antibody discovery platform to generate pan-reactive antibodies that cross-react with numerous mammalian species to enable target validation. Use a single reagent as a human antibody, a mouse antibody (anti-mouse), a rat antibody (anti-rat), a NHP antibody (anti-NHP) (including Rhesus antibodies, marmoset antibodies, and macaque antibodies), a cynomolgus antibody (anti-cyno), a bat antibody (anti-bat), a ferret antibody (anti-ferret), a rabbit antibody (anti-rabbit). validation and translational research across species.

  • Validate Across Species: Assess target relevance in mice, rats, NHPs, and other mammalian models. Isolate mAbs against targets from any mammalian species: mouse, cynomolgus, rhesus, marmoset, rat, rabbit, ferret, pig, bat, guinea pig, and more.
  • One mAb for Preclinical Studies: Confirm safety and efficacy in preclinical models and localization in human tissues with the same mAb.

 

Project Workflow

 

our custom antibody services leverage our proven antibody discovery platform to generate pan-reactive antibodies that cross-react with numerous mammalian species. Our antibody discovery platform utilizes chickens as a divergent host species and immunizes with mRNA and Lipoparticles (virus-like particles, VLPs) that present high-concentration and structurally-intact membrane proteins, to generate antibodies against native antigens. Monoclonal antibody reagents are screened using optimized phage display protocols to isolate rare mAbs even against membrane proteins embedded in a lipid bilayer. Antibodies are validated and characterized to ensure high-quality antibody reagents that are compatible with flow cytometry, IHC, immunofluorescence, western blot, and numerous other assays.

 

Contact Us to Get a Quote and Start a Project

 

Frequently Asked Questions